Recombinant Human Fibroblast Activation Protein, Alpha, His-tagged

• Cat.No.: FAP-426H
• Product Overview: Recombinant human FAP (amino acids 29-end) with C-terminal His tag, MW=85.5 kDa, expressed in aBaculovirus infected Sf9cell expression system.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Protein Length: 29-end a.a.
• Description: Fibroblast activation protein, alpha, also known as FAP, is a human gene and encodes for a protease. The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Fomulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT.
• Purity: >90%.
• Stability: >6 months at -80°C.

Gene Information

• Gene Name: FAP fibroblast activation protein, alpha [ Homo sapiens ]
• Synonyms: FAP; fibroblast activation protein, alpha; DPPIV; seprase; Integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase; DKFZp686G13158; EC 3.4.21;FAPA; Fibroblast activation protein alpha
• Gene ID: 2191
• mRNA Refseq: NM_004460
• Protein Refseq: NP_004451
• MIM: 600403
• UniProt ID: Q12884
• Chromosome Location: 2q23
• Function: dipeptidyl-peptidase activity; metalloendopeptidase activity; peptidase activity; protein homodimerization activity; serine-type endopeptidase activity