Recombinant Human FGFR1OP, GST-tagged

• Cat.No.: FGFR1OP-12879H
• Product Overview: Recombinant Human FGFR1OP protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-374a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: FGFR1OP FGFR1 oncogene partner [ Homo sapiens ]
• Official Symbol: FGFR1OP
• Synonyms: FGFR1OP; FGFR1 oncogene partner; FOP; fibroblast growth factor receptor 1 oncogene partner
• Gene ID: 11116
• mRNA Refseq: NM_007045
• Protein Refseq: NP_008976
• MIM: 605392
• UniProt ID: O95684
• Chromosome Location: 6q27
• Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem; Loss of proteins required for interphase microtubule organization??from the centrosome, organism-specific biosystem; Mitotic G2-G2/M phases, organism-specific biosystem
• Function: protein binding; protein homodimerization activity; protein kinase binding; protein tyrosine kinase inhibitor activity