Recombinant Human FGFR1 Oncogene Partner, His-tagged

• Cat.No.: FGFR1OP-6790H
• Product Overview: Recombinant humanFGFR1OP protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography

Specification

• Cat. No.: FGFR1OP-6790H
• Description: FGFR1OP, also knownas FGFR1 oncogene partner, belongs to the FGFR1OP family. This protein is alargely hydrophilic protein postulated to be a leucine-rich protein familymember. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and thefibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases ofmyeloproliferative disorder. The resulting chimeric protein contains theN-terminal leucine-rich region of this encoded protein fused to the catalyticdomain of FGFR1. This gene is thought to play an important role in normalproliferation and differentiation of the erythroid lineage
• Form: Liquid. 20mMTris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT
• Molecular Weight: 43.5 kDa (403aa),confirmed by MALDI-TOF
• Purity: > 85% by SDS -PAGE
• Concentration: 1mg/ml (determinedby Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMAATAA AVVAEEDTEL RDLLVQTLEN SGVLNRIKAE LRAAVFLALE EQEKVENKTPLVNESLKKFL NTKDGRLVAS LVAEFLQFFN LDFTLAVFQP ETSTLQGLEG RENLARDLGI IEAEGTVGGPLLLEVIRRCQ QKEKGPTTGE GALDLSDVHS PPKSPEGKTS AQTTPSKKAN DEANQSDTSV SLSEPKSKSSLHLLSHETKI GSFLSNRTLD GKDKAGLCPD EDDMEGDSFF DDPIPKPEKT YGLRKEPRKQ AGSLASLSDAPPLKSGLSSL AGAPSLKDSE SKRGNTVLKD LKLISDKIGS LGLGTGEDDD YVDDFNSTSH RSEKSEISIGEEIEEDLSVE IDDINTSDKL DDLTQDLTVS QLSDVADYLE DVA
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles

Gene Information

• Gene Name: FGFR1OP FGFR1 oncogene partner[Homo sapiens]
• Official Symbol: FGFR1OP
• Synonyms: FGFR1OP; FGFR1 oncogene partner;FOP; OTTHUMP00000017612; OTTHUMP00000017613; fibroblast growth factorreceptor 1 oncogene partner
• Gene ID: 11116
• mRNA Refseq: NM_194429
• Protein Refseq: NP_919410
• MIM: 605392
• UniProt ID: O95684
• Chromosome Location: 6q27
• Function: protein binding; proteinhomodimerization activity; protein kinase binding; protein tyrosine kinaseinhibitor activity