Recombinant Human FBXO32, GST-tagged
Cat.No. : | FBXO32-12796H |
Product Overview : | Recombinant Human FBXO32 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
Availability | March 13, 2025 |
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Species : | Human |
Source : | E.coli |
Tag : | GST |
Protein Length : | C-term-217a.a. |
Description : | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name | FBXO32 F-box protein 32 [ Homo sapiens ] |
Official Symbol | FBXO32 |
Synonyms | FBXO32; F-box protein 32; F box only protein 32; F-box only protein 32; ATROGIN1; Fbx32; MAFbx; atrogin 1; atrogin-1; muscle atrophy F-box protein; FLJ32424; MGC33610; |
Gene ID | 114907 |
mRNA Refseq | NM_001242463 |
Protein Refseq | NP_001229392 |
MIM | 606604 |
UniProt ID | Q969P5 |
Chromosome Location | 8q24.13 |
Pathway | FoxO family signaling, organism-specific biosystem; Monoamine Transport, organism-specific biosystem; |
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Not For Human Consumption!
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