Recombinant Human FBXO2, GST-tagged

• Cat.No.: FBXO2-12788H
• Product Overview: Recombinant Human FBXO2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-296a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: FBXO2 F-box protein 2 [ Homo sapiens ]
• Official Symbol: FBXO2
• Synonyms: FBXO2; F-box protein 2; F box only protein 2 , OCP1, organ of Corti protein 1; F-box only protein 2; Fbg1; Fbs1; FBX2; Nfb42; F-box gene 1; organ of Corti protein 1; FBG1; OCP1; NFB42
• Gene ID: 26232
• mRNA Refseq: NM_012168
• Protein Refseq: NP_036300
• MIM: 607112
• UniProt ID: Q9UK22
• Chromosome Location: 1p36.21
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem
• Function: beta-amyloid binding; glycoprotein binding; sugar binding; ubiquitin-protein ligase activity