Recombinant Human Fas Ligand (TNF superfamily, member 6), His-tagged

• Cat.No.: FASLG-5412H
• Product Overview: Recombinant Human soluble Fas Ligandcontains 175 amino acid residues and comprises the TNF homologous region ofFast plus an eight His-Tag.

Specification

• Species: Human
• Source: CHO
• Tag: His
• Description: FASLG is a type-IItransmembrane protein that belongs to the tumor necrosis factor (TNF) family.Its binding with its receptor induces apoptosis. Fas ligand/receptorinteractions play an important role in the regulation of the immune systemand the progression of cancer.
• Form: Lyophilized withoutadditives.
• Molecular Weight: 17.9 kDa
• Purity: <95% by RP-HPLC and SDS-PAGE.
• Endotoxin Level: <0.1 ng/ug
• Biological Activity: Determined by itsability to induce cytotoxicity in Jurkat cells in the absence of anycross-linking. The EDSO for this effect is <10.0 ng/ml.
• Specific Activity: < 1 x 105units/mg
• Reconstitution: Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions.
• Storage: Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -20°C.Avoid repeated freeze-thaw cycles.
• OfficialSymbol: FASLG

Gene Information

• Gene Name: FASLG Fas ligand (TNFsuperfamily, member 6) [ Homo sapiens ]
• Synonyms: FASLG; Fas ligand(TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand;apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand)superfamily, member 6
• Gene ID: 356
• mRNA Refseq: NM_000639
• Protein Refseq: NP_000630
• MIM: 134638
• UniProt ID: P48023
• Chromosome Location: 1q23
• Pathway: Activationof Pro-Caspase 8; Africantrypanosomiasis; Allograft rejection;Apoptosis; Autoimmune thyroid disease; Calcineurin-regulatedNFAT-dependent transcription in lymphocytes; Calcium signaling in the CD4+ TCR pathway; Caspase-8 is formed from procaspase-8; Death Receptor Signalling; FoxO family signaling; Influenza A; MAPKsignaling pathway; Measles; Pathways in cancer; Type I diabetes mellitus
• Function: cytokine activity;protein binding; receptor binding; tumor necrosis factor receptor binding