Recombinant Human ETF1, GST-tagged

• Cat.No.: ETF1-12564H
• Product Overview: Recombinant Human ETF1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in coding and non-coding transcript variants. Pseudogenes of this gene are found on chromosomes 5, 7 and X.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-404a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ETF1 eukaryotic translation termination factor 1 [ Homo sapiens ]
• Official Symbol: ETF1
• Synonyms: ETF1; eukaryotic translation termination factor 1; ERF, ERF1, SUP45L1; eukaryotic peptide chain release factor subunit 1; eRF1; polypeptide chain release factor 1; RF1; sup45 (yeast omnipotent suppressor 45) homolog like 1; TB3 1; protein Cl1; eukaryotic release factor 1; sup45 (yeast omnipotent suppressor 45) homolog-like 1; ERF; ERF1; TB3-1; D5S1995; SUP45L1; MGC111066
• Gene ID: 2107
• mRNA Refseq: NM_004730
• Protein Refseq: NP_004721
• MIM: 600285
• UniProt ID: P62495
• Chromosome Location: 5q31.2
• Pathway: Eukaryotic Translation Termination, organism-specific biosystem; Gene Expression, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Nonsense Mediated Decay Enhanced by the Exon Junction Complex, organism-specific biosystem; Nonsense Mediated Decay Independent of the Exon Junction Complex, organism-specific biosystem; Nonsense-Mediated Decay, organism-specific biosystem; Translation, organism-specific biosystem
• Function: RNA binding; protein binding; ribosome binding; translation release factor activity; translation release factor activity, codon specific; translation termination factor activity

Reviews

11/25/2022

What sets this protein apart is the outstanding technical support provided by the manufacturer.

09/20/2022

Its versatility allows me to explore its diverse roles in various biochemical and biological processes accurately.

07/18/2019

The ETF1 Protein is of exceptional quality and is precisely tailored to meet my experimental requirements.

Q&As

Are there any ongoing clinical trials related to ETF1 protein disorders?

There may be clinical trials evaluating potential treatments or interventions for ETF1 protein disorders, and individuals and families affected by these disorders can consider participating in such trials.

What are the symptoms of metabolic disorders caused by ETF1 protein dysfunction?

Symptoms may include muscle weakness, lethargy, hypoglycemia, metabolic acidosis, and in some cases, developmental delays and neurological symptoms.

Can ETF1 protein disorders be detected before birth?

Yes, prenatal testing through genetic screening can detect mutations in the ETF1 gene, allowing for early intervention and management.

How are ETF1 protein disorders diagnosed?

Diagnosis typically involves biochemical testing, genetic testing, and metabolic screening to identify abnormalities in fatty acid metabolism.

Can ETF1 protein disorders affect individuals of all ages?

Yes, ETF1 protein disorders can affect individuals of all ages, from newborns to adults, and may present with different symptoms at different stages of life.