Recombinant Human ERCC6, His-tagged

• Cat.No.: ERCC6-2672H
• Product Overview: Recombinant Human ERCC6 with a His tag is expressed inE. coli.MW: 130±5 KDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The ERCC6 protein is a DNA-binding protein important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity; there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites.
• Formulation: 20% Glycerol solution at 0.20 mg/ml.
• Activity: It may be used on the repair of RNA-polymerase II transcribed genes.
• Storage: Store at -80°C. At least 1 year at -80°C.

Gene Information

• Gene Name: ERCC6 excision repair cross-complementing rodent repair deficiency, complementation group 6 [ Homo sapiens ]
• Synonyms:
  ERCC6; excision repair cross-complementing rodent repair deficiency, complementation group 6; ATP-dependent helicase ERCC6; Cockayne syndrome B protein; Cockayne syndrome group B protein; DNA excision repair protein ERCC-6; Rad26 homolog; cockayne syndrome protein CSB
• Gene ID: 2074
• mRNA Refseq: NM_000124
• Protein Refseq: NP_000115
• MIM: 609413
• UniProt ID: Q03468
• Chromosome Location: 10q11.23
• Pathway: Nucleotide excision repair; DNA Repair
• Function: ATP binding; DNA binding; NOT DNA helicase activity; DNA-dependent ATPase activity; chromatin binding; protein C-terminus binding; protein N-terminus binding; transcription elongation regulator activity