Recombinant Human EPH Receptor A3, His-tagged

• Cat.No.: EPHA3-1880H
• Product Overview: Recombinant humanEPHA3 cytoplasmic domain (aa 569-983) with His tag. Activated in vitro viaauto-phosphorylation.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 569-983 a.a.
• Description: EPHA3 (ephrin type-Areceptor 3) is a protein that inhumans is encoded by the EPHA3 gene. This gene belongs to the ephrin receptorsubfamily of the protein-tyrosine kinase family. EPH and EPH-related receptorshave been implicated in mediating developmental events, particularly in thenervous system. Receptors in the EPH subfamily typically have a single kinasedomain and an extracellular region containing a Cys-rich domain and 2fibronectin type III repeats. The ephrin receptors are divided into 2 groupsbased on the similarity of their extracellular domain sequences and theiraffinities for binding ephrin-A and ephrin-B ligands.
• Form: Liquid in 20 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.05% Triton X-100 + 2 mM DTT +50% glycerol.
• Molecular Weight: 50.8 kDa
• Purity: ≥ 90% as determinedby SDS-PAGE analysis.
• Specific Activity: 1000 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg oftotal protein at 30°C. Activity determined at a final protein concentrationof 1 μg/ml.
• Concentration: 0.4 mg/ml
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: EPHA3

Gene Information

• Gene Name: EPHA3 EPH receptor A3 [ Homosapiens ]
• Synonyms: EPHA3; EPH receptorA3; EK4;ETK; HEK; ETK1; HEK4; TYRO4; ephrin type-A receptor 3; EPH-like kinase 4;OTTHUMP00000213903; OTTHUMP00000213904; OTTHUMP00000213905; human embryokinase 1; eph-like tyrosine kinase 1; TYRO4 protein tyrosine kinase;tyrosine-protein kinase receptor ETK1
• Gene ID: 2042
• mRNA Refseq: NM_005233
• Protein Refseq: NP_005224
• MIM: 179611
• UniProt ID: P29320
• Chromosome Location: 3p11.2
• Pathway: Axon guidance; EPHAforward signaling; EphrinA-EPHA pathway
• Function: ATP binding;GPI-linked ephrin receptor activity; nucleotide binding; protein binding;receptor activity