Recombinant Human EIF3E

Description :	eIF3e is part of the eIF3 complex, which is composed of at least 12 subunits. It binds the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA. It can bind the COP9 signalosome and the 26S proteasome, possibly having regulatory functions in both protein translation and degradation. Reducing its expression by RNA interference in HeLa cells markedly alters mitosis progression and defects in spindle formation, chromosome segregation and cytokinesis are observed.
Protein length :	445 amino acids
Molecular Weight :	75.020kDa inclusive of tags
Source :	Wheat germ
Form :	Liquid
Purity :	Proprietary Purification
Storage buffer :	pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage :	Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids :	MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQG KLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQ LKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADK HGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPA TDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNS VSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQP QYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKV IQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLV NDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKL NMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSP YQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQ DSGFY
Tag :	Non

Gene Name	EIF3E eukaryotic translation initiation factor 3, subunit E [ Homo sapiens ]
Official Symbol	EIF3E
Synonyms	EIF3E; eukaryotic translation initiation factor 3, subunit E; EIF3S6, eukaryotic translation initiation factor 3, subunit 6 48kDa , INT6; eukaryotic translation initiation factor 3 subunit E; eIF3 p48; eIF3e;
Gene ID	3646
mRNA Refseq	NM_001568
Protein Refseq	NP_001559
MIM	602210
Uniprot ID	P60228
Chromosome Location	8q22-q23
Pathway	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; Formation of a pool of free 40S subunits, organism-specific biosystem; Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystem;
Function	protein N-terminus binding; protein binding; translation initiation factor activity; contributes_to translation initiation factor activity; contributes_to translation initiation factor activity;

COA

Cat.No. :	EIF3E-26385TH
Product Overview :	Recombinant full length Human eIF3e with N terminal proprietary tag; Predicted MWt 75.02 kDa inclusive of tag.