Recombinant Human EIF2C2, His-tagged

• Cat.No.: EIF2C2-12358H
• Product Overview: Recombinant Human EIF2C2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 77-377a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: EIF2C2 eukaryotic translation initiation factor 2C, 2 [ Homo sapiens ]
• Official Symbol: EIF2C2
• Synonyms: EIF2C2; eukaryotic translation initiation factor 2C, 2; protein argonaute-2; AGO2; argonaute 2; Q10; PPD; hAgo2; eIF2C 2; eIF-2C 2; argonaute2; protein slicer; PAZ Piwi domain protein; MGC3183
• Gene ID: 27161
• mRNA Refseq: NM_001164623
• Protein Refseq: NP_001158095
• MIM: 606229
• UniProt ID: Q9UKV8
• Chromosome Location: 8q24
• Pathway: Gene Expression, organism-specific biosystem; MicroRNA (miRNA) Biogenesis, organism-specific biosystem; Post-transcriptional Silencing By Small RNAs, organism-specific biosystem; Pre-NOTCH Expression and Processing, organism-specific biosystem; Pre-NOTCH Transcription and Translation, organism-specific biosystem; Regulatory RNA pathways, organism-specific biosystem; Signal Transduction, organism-specific biosystem
• Function: RNA 7-methylguanosine cap binding; endonuclease activity; endoribonuclease activity, cleaving siRNA-paired mRNA; hydrolase activity; metal ion binding; protein binding; siRNA binding; contributes_to siRNA binding; translation initiation factor activity