Recombinant Human DUSP12 Protein, Myc/DDK-tagged

• Cat.No.: DUSP12-01H
• Product Overview: Recombinant protein of human dual specificity phosphatase 12 (DUSP12) with a C-Myc/DDK tag was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.
• Molecular Mass: 37.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: DUSP12 dual specificity phosphatase 12 [ Homo sapiens (human) ]
• Official Symbol: DUSP12
• Synonyms: DUSP12; dual specificity phosphatase 12; YVH1; DUSP1; dual specificity protein phosphatase 12; YVH1 protein-tyrosine phosphatase ortholog; dual specificity tyrosine phosphatase YVH1; serine/threonine specific protein phosphatase; EC 3.1.3.16; EC 3.1.3.48
• Gene ID: 11266
• mRNA Refseq: NM_007240
• Protein Refseq: NP_009171
• MIM: 604835
• UniProt ID: Q9UNI6