Recombinant Human DPP8 Protein (M1-I898), His tagged

• Cat.No.: DPP8-0390H
• Product Overview: Recombinant Human 8His-TEV-DPP 8(M1-I898 end) Protein was expressed in Insect cell.

Specification

• Description: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8. Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation. The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Protein length: M1-I898
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: DPP8 dipeptidyl-peptidase 8 [ Homo sapiens (human) ]
• Official Symbol: DPP8
• Synonyms: DPP8; dipeptidyl-peptidase 8; dipeptidylpeptidase 8; dipeptidyl peptidase 8; dipeptidyl peptidase IV related protein 1; dipeptidyl peptidase VIII; DP8; DPRP1; FLJ14920; FLJ20283; MGC26191; MSTP141; prolyl dipeptidase DPP8; DPRP-1; DPP VIII; dipeptidyl peptidase IV-related protein 1; dipeptidyl peptidase IV-related protein-1
• Gene ID: 54878
• mRNA Refseq: NM_017743
• Protein Refseq: NP_060213
• MIM: 606819
• UniProt ID: Q6V1X1