Recombinant Human DNM1 protein, MYC/DDK-tagged

• Cat.No.: DNM1-06H
• Product Overview: Recombinant Human DNM1, transcript variant 2, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 95.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: DNM1 dynamin 1 [ Homo sapiens ]
• Official Symbol: DNM1
• Synonyms: DNM1; dynamin 1; DNM; dynamin-1
• Gene ID: 1759
• mRNA Refseq: NM_001005336
• Protein Refseq: NP_001005336
• MIM: 602377
• UniProt ID: Q05193
• Chromosome Location: 9q34
• Pathway: Axon guidance, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CXCR3-mediated signaling events, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Developmental Biology, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem
• Function: GTP binding; GTPase activity; hydrolase activity; identical protein binding; nucleotide binding; protein binding