Recombinant Human DNASE1 Protein (Gly19-Ala259), His tagged

Description :	Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation.
Source :	E. coli
Species :	Human
Tag :	His
Form :	Lyophilized powder/frozen liquid
Molecular Mass :	27.9 kDa
Protein length :	Gly19-Ala259
Purity :	>90% as determined by SDS-PAGE
Notes :	For research use only.
Storage :	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
Storage Buffer :	Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
Reconstitution :	Reconstitute in sterile water for a stock solution.
Shipping :	They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Name	DNASE1 deoxyribonuclease I [ Homo sapiens (human) ]
Official Symbol	DNASE1
Synonyms	DNASE1; deoxyribonuclease I; DNL1; deoxyribonuclease-1; Dornase alfa; DNase I, lysosomal; human urine deoxyribonuclease I; DRNI; FLJ38093; FLJ44902; DKFZp686H0155;
Gene ID	1773
mRNA Refseq	NM_005223
Protein Refseq	NP_005214
MIM	125505
UniProt ID	P24855