Recombinant Human DNA-damage-inducible Transcript 3
Cat.No. : | DDIT3-130H |
Product Overview : | Recombinant Human DNA-damage-inducible transcript 3 protein expressed inE.coliencodes full length amino acids and has a molecular mass of 52 kDa. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Description : | GADD 153 has been described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. GADD153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and merabolic perturbations. GADD153 functions to block cells in G1 to S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD153 dimers away from "classical" C/EBP binding sites, recognizing instead unique "nonclassical" sites. |
Formulation : | Recombinant Human GADD153 protein at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. |
Application : | •ELISA •Inhibition Assays •Western Blotting. |
Characterization : | On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 52 kDa. |
Storage & Stability : | Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months. |
Full Length : | Full L. |
Publications : |
Is there a common upstream link for autophagic and apoptotic cell death in human high-grade gliomas? (2011)
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Gene Name | DDIT3 DNA-damage-inducible transcript 3 [ Homo sapiens ] |
Synonyms | DDIT3; DNA-damage-inducible transcript 3; CHOP; CEBPZ; CHOP10; GADD153; MGC4154; C/EBP zeta; DDIT-3; Growth arrest and DNA-damage-inducible protein GADD153; C/EBP-homologous protein; C/EBP homologous protein; CCAAT/enhancer-binding protein homologous protein; growth arrest- and DNA damage-inducible |
Gene ID | 1649 |
mRNA Refseq | NM_004083 |
Protein Refseq | NP_004074 |
MIM | 126337 |
UniProt ID | P35638 |
Chromosome Location | 12q13.1-q13.2 |
Pathway | MAPK signaling pathway; Diabetes pathways |
Function | protein dimerization activity; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity |
◆ Recombinant Proteins | ||
DDIT3-4948H | Recombinant Human DNA-Damage-Inducible Transcript 3, His-tagged | +Inquiry |
DDIT3-130H | Recombinant Human DNA-damage-inducible Transcript 3 | +Inquiry |
DDIT3-3923H | Recombinant Human DDIT3 protein, His-tagged | +Inquiry |
DDIT3-217H | Recombinant Human DDIT3 Protein, GST/His-tagged | +Inquiry |
DDIT3-859H | Recombinant Human DDIT3 Protein, GST-His-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
DDIT3-7027HCL | Recombinant Human DDIT3 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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