Recombinant Human DLL1, Fc-tagged

• Cat.No.: DLL1-26673TH
• Product Overview: Signal peptide and extracellular domain of human DLL1 (aa 1-545) are fused at the C-terminus to the Fc portion of human IgG1.

Specification

• Description: DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.
• Source: CHO cells
• Species: Human
• Tag: Fc
• Form: Lyophilized. Contains PBS.
• Bio-activity: Inhibits adipogenesis of 3T3L-1 cells. Induces Hes-1 in 3T3L-1 cells.
• Molecular Mass: ~100kDa (SDS-PAGE)
• Endotoxin: <0.01EU/μg purified protein (LAL test; Lonza).
• Purity: ≥90% (SDS-PAGE)
• Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°CLong Term Storage: -20°CAfter reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
• Reconstitution: Reconstitute in distilled water.

Gene Information

• Gene Name: DLL1 delta-like 1 (Drosophila) [ Homo sapiens (human) ]
• Official Symbol: DLL1
• Synonyms: DLL1; DL1; Delta; DELTA1; delta-like 1 (Drosophila); delta-like protein 1; H-Delta-1; drosophila Delta homolog 1
• Gene ID: 28514
• mRNA Refseq: NM_005618
• Protein Refseq: NP_005609
• MIM: 606582
• UniProt ID: O00548
• Chromosome Location: 6q27
• Pathway: Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FBXW7 Mutants and NOTCH1 in Cancer
• Function: Notch binding; calcium ion binding; protein binding