Recombinant Human Di-Ubiquitin Protein (K63 Linked)

• Cat.No.: Di-Ubiquitin-43H
• Product Overview: Recombinant Human Di-Ubiquitin Protein (K63 Linked) without tag was expressed in E. coli

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Poly-ubiquitination of target proteins through K63 has recently become the focus of intense study. The topology of this linkage type is quite different from polyubiquitin linked through lysine 48. Modification of proteins by K63-linked poly-ubiquitination has been implicated in, among other cellular processes, the regulation of the DNA damage response, endosomal sorting, autophagy of misfolded/aggregated proteins, and neurodegeneration. These di-ubiquitin chains are generated from the enzymatic linkage of wild-type ubiquitin through lysine 63. The most distal ubiquitin contains an arginine substitution for the lysine at position 63, limiting chain length.
• Molecular Mass: 17,139.7 Da
• Storage: At -80 centigrade, avoid freeze/thaw cycles
• Storage Buffer: 20 mM Tris, pH 7.5, 150 mM NaCl, 1 mM EDTA

Gene Information

• Official Symbol: Di-Ubiquitin
• Synonyms: Di-Ubiquitin; Ub2