Recombinant Human DHDH, His-tagged

• Cat.No.: DHDH-11965H
• Product Overview: Recombinant Human DHDH protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-334a.a.
• Description: This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: DHDH dihydrodiol dehydrogenase (dimeric) [ Homo sapiens ]
• Official Symbol: DHDH
• Synonyms: DHDH; dihydrodiol dehydrogenase (dimeric); trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; HUM2DD; D-xylose 1-dehydrogenase; 3-deoxyglucosone reductase; D-xylose-NADP dehydrogenase; 2DD
• Gene ID: 27294
• mRNA Refseq: NM_014475
• Protein Refseq: NP_055290
• MIM: 606377
• UniProt ID: Q9UQ10
• Chromosome Location: 19q13.3
• Pathway: Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P450, conserved biosystem; Pentose and glucuronate interconversions, organism-specific biosystem; Pentose and glucuronate interconversions, conserved biosystem
• Function: D-xylose 1-dehydrogenase (NADP+) activity; NAD(P)+ transhydrogenase activity; electron carrier activity; nucleotide binding; oxidoreductase activity; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity