Recombinant Human DDX41 Protein, GST-tagged

• Cat.No.: DDX41-2488H
• Product Overview: Human DDX41 full-length ORF ( NP_057306.2, 1 a.a. - 622 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 96.2 kDa
• AA Sequence: MEESEPERKRARTDEVPAGGSRSEA EDEDDEDYVPYVPLRQRRQLLLQKL LQRRRKGAAEEEQQDSGSEPRGDED DIPLGPQSNVSLLDQHQHLKEKAEA RKESAKEKQLKEEEKILESVAEGRA LMSVKEMAKGITYDDPIKTSWTPPR YVLSMSEERHERVRKKYHILVEGDG IPPPIKSFKEMKFPAAILRGLKKKG IHHPTPIQIQGIPTILSGRDMIGIA FTGSGKTLVFTLPVIMFCLEQEKRL PFSKREGPYGLIICPSRELARQTHG ILEYYCRLLQEDSSPLLRCALCIGG MSVKEQMETIRHGVHMMVATPGRLM DLLQKKMVSLDICRYLALDEADRMI DMGFEGDIRTIFSYFKGQRQTLLFS ATMPKKIQNFAKSALVKPVTINVGR AGAASLDVIQEVEYVKEEAKMVYLL ECLQKTPPPVLIFAEKKADVDAIHE YLLLKGVEAVAIHGGKDQEERTKAI EAFREGKKDVLVATDVASKGLDFPA IQHVINYDMPEEIENYVHRIGRTGR SGNTGIATTFINKACDESVLMDLKA LLLEAKQKVPPVLQVLHCGDESMLD IGGERGCAFCGGLGHRITDCPKLEA MQTKQVSNIGRKDYLAHSSMDF
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 [ Homo sapiens ]
• Official Symbol: DDX41
• Synonyms: DDX41; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; probable ATP-dependent RNA helicase DDX41; ABS; MGC8828; 2900024F02Rik; DEAD box protein 41; putative RNA helicase; DEAD-box protein abstrakt; DEAD box protein abstrakt homolog
• Gene ID: 51428
• mRNA Refseq: NM_016222
• Protein Refseq: NP_057306
• MIM: 608170
• UniProt ID: Q9UJV9

Reviews

04/16/2020

Compatibility with standard laboratory instruments made the product user-friendly in our well-equipped facility.

11/11/2019

Our suggestions for enhancements were acknowledged, fostering a collaborative relationship with the product's provider.

01/12/2019

Clear and comprehensive training materials provided a solid foundation for understanding the product's application.

Q&As

In which cellular compartments is DDX41 predominantly localized?

DDX41 is predominantly localized in the cytoplasm of cells, where it carries out its functions in nucleic acid recognition and immune sensing.

What is the primary function of DExD/H-box helicase 41 (DDX41) in cellular processes and nucleic acid metabolism?

DExD/H-box helicase 41 (DDX41) functions in cellular processes, primarily playing a role in nucleic acid metabolism and immune responses.

How does DDX41 recognize and interact with nucleic acids, including RNA and DNA?

DDX41 recognizes and interacts with nucleic acids, including RNA and DNA, through its DExD/H-box helicase domain.

What is the role of DDX41 in innate immune responses, particularly in sensing viral or microbial infections?

The role of DDX41 in innate immune responses involves sensing viral or microbial infections and triggering antiviral signaling pathways.

What diseases or conditions are associated with dysregulation or abnormal expression of DDX41?

Dysregulation or abnormal expression of DDX41 is associated with conditions such as myelodysplastic syndromes and certain cancers.

How does DDX41 contribute to the activation of antiviral signaling pathways, such as the interferon response?

DDX41 contributes to the activation of antiviral signaling pathways, including the induction of interferon responses against viral infections.

Are there therapeutic implications or potential targets related to DDX41 in diseases involving immune responses?

There are potential therapeutic implications related to DDX41 in diseases involving immune responses, making it a target for drug development.