Recombinant Human DDX23, GST-tagged

• Cat.No.: DDX23-11896H
• Product Overview: Recombinant Human DDX23 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 614-820a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [ Homo sapiens ]
• Official Symbol: DDX23
• Synonyms: DDX23; DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; PRP28 homolog, yeast; probable ATP-dependent RNA helicase DDX23; prp28; PRPF28; U5 100K; PRP28p homolog; DEAD box protein 23; U5 snRNP 100 kD protein; 100 kDa U5 snRNP-specific protein; U5-100K; U5-100KD; MGC8416
• Gene ID: 9416
• mRNA Refseq: NM_004818
• Protein Refseq: NP_004809
• MIM: 612172
• UniProt ID: Q9BUQ8
• Chromosome Location: 12q13.11
• Pathway: Gene Expression, organism-specific biosystem; Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem; Spliceosome, organism-specific biosystem; Spliceosome, conserved biosystem; Spliceosome, U4/U6.U5 tri-snRNP, organism-specific biosystem; mRNA Splicing, organism-specific biosystem; mRNA Splicing - Major Pathway, organism-specific biosystem
• Function: ATP binding; ATP-dependent RNA helicase activity; NOT ATP-dependent helicase activity; helicase activity; hydrolase activity; nucleic acid binding; nucleotide binding; protein binding