Recombinant Human DDX1

• Cat.No.: DDX1-26545TH
• Product Overview: Recombinant full length Human DDX1 with N-terminal proprietary tag. Predicted MW 107.14kDa.

Specification

• Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.
• Protein length: 740 amino acids
• Molecular Weight: 107.140kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Highest levels of transcription in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin including the retina, brain, and spinal cord.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGG DVLMAAETGSGKTGAFSIPVIQIVYETLKDQQEGKKGKTT IKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWH GCRATKGLMKGKHYYEVSCHDQGLCRVGWSTMQASLDLGT DKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDK GHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKF NFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQT KFLPNAPKALIVEPSRELAEQTLNNIKQFKKYIDNPKLRE LLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLN LSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKR LQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDT VHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGAN SPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCD NLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLER FKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYV HRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYN TRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVP VDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALEK EAQTSFLHLGYLPNQLFRTF
• Sequence Similarities: Belongs to the DEAD box helicase family. DDX1 subfamily.Contains 1 B30.2/SPRY domain.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.
• Tag: Non

Gene Information

• Gene Name: DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 [ Homo sapiens ]
• Official Symbol: DDX1
• Synonyms: DDX1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 1; ATP-dependent RNA helicase DDX1; DBP RB
• Gene ID: 1653
• mRNA Refseq: NM_004939
• Protein Refseq: NP_004930
• MIM: 601257
• Uniprot ID: Q92499
• Chromosome Location: 2p24
• Pathway: mRNA processing, organism-specific biosystem
• Function: ATP binding; ATP-dependent helicase activity; DNA binding; DNA/RNA helicase activity; RNA binding