Recombinant Human DBNL protein, His-tagged

• Cat.No.: DBNL-02H
• Product Overview: Recombinant protein from the full-length sequence of Homo sapiens drebrin like (DBNL), transcript variant 1 (NM_014063), with a His tag was expressed in human cells.

Specification

• Description: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
• Source: Human cells
• Species: Human
• Tag: His
• Molecular Mass: 48.2 kDa
• Endotoxin: < 0.1 ng/μg of protein (< 1 EU/μg)
• Purity: > 90 % by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
• Storage Buffer: Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives

Gene Information

• Gene Name: DBNL drebrin like [ Homo sapiens (human) ]
• Official Symbol: DBNL
• Synonyms: DBNL; drebrin like; ABP1; HIP55; SH3P7; HIP-55; drebrin-like protein; HPK1-interacting protein of 55 kDa; SH3 domain-containing protein 7; actin-binding protein 1; cervical SH3P7; cervical mucin-associated protein; drebrin-F; src homology 3 domain-containing protein HIP-55
• Gene ID: 28988
• mRNA Refseq: NM_014063
• Protein Refseq: NP_054782
• MIM: 610106
• UniProt ID: Q9UJU6