Recombinant Human CXCR3, GST-tagged

• Cat.No.: CXCR3-28064TH
• Product Overview: Recombinant Human CXCR3(121 a.a. - 220 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: GST
• Description: This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4.
• Molecular Mass: 36.74 kDa
• AA Sequence: SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHD ERLNATHCQYNFPQVGRTALRVLQL
• Applications: ELISA; WB-Re; AP; Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CXCR3 chemokine (C-X-C motif) receptor 3 [ Homo sapiens (human) ]
• Official Symbol: CXCR3
• Synonyms: CXCR3; chemokine (C-X-C motif) receptor 3; G protein coupled receptor 9 , GPR9; C-X-C chemokine receptor type 3; CD183; CKR L2; CMKAR3; IP10 R; MigR
• Gene ID: 2833
• mRNA Refseq: NM_001142797
• Protein Refseq: NP_001136269
• MIM: 300574
• UniProt ID: P49682
• Chromosome Location: Xq13
• Pathway: Chemokine receptors bind chemokines; Chemokine signaling pathway; Cytokine-cytokine receptor interaction
• Function: C-X-C chemokine binding; C-X-C chemokine receptor activity; chemokine receptor activity