Recombinant Human CTNNB1 Protein, His-tagged

• Cat.No.: CTNNB1-10H
• Product Overview: Recombinant full-length human Catenin beta was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.

Specification

• Description: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
• Source: Insect cell
• Species: Human
• Tag: His
• Molecular Mass: Approx 100 kDa
• Purity: > 80%
• Stability: One year at -70 centigrade from data of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.05 μg/μL
• Storage Buffer: Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, DTT, 25% glycerol.
• Shipping: Dry ice

Gene Information

• Gene Name: CTNNB1 catenin beta 1 [ Homo sapiens (human) ]
• Official Symbol: CTNNB1
• Synonyms: CTNNB1; catenin beta 1; catenin beta-1; catenin (cadherin-associated protein), beta 1, 88kDa; EVR7; CTNNB; MRD19; NEDSDV; armadillo
• Gene ID: 1499
• mRNA Refseq: NM_001904
• Protein Refseq: NP_001895
• MIM: 116806
• UniProt ID: P35222