Recombinant Human CTDSP1, His-tagged

• Cat.No.: CTDSP1-28022TH
• Product Overview: Recombinant full length Human CTDSP1 (amino acids 1-260) with an N terminal His tag; 280 amino acids with a predicted MWt 31.2kDa including tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 260 amino acids
• Description: This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Conjugation: HIS
• Molecular Weight: 31.200kDa inclusive of tags
• Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 1mM DTT, pH 8
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MDSSAVITQISKEEARGPLR GKGDQKSAAS QKPRSRGILH SLFCCVCRDDGEALPAHSGA PLLVEENGAI PKTPVQYLLP EAKAQDSDKICVVIDLDETL VHSSFKPVNN ADFIIPVEID GVVHQVYVLKRPHVDEFLQR MGELFECVLF TASLAKYADP VADLLDKWGAFRARLFRESC VFHRGNYVKD LSRLGRDLRR VLILDNSPASYVFHPDNAVP VASWFDNMSD TELHDLLPFF EQLSRVDDVYSVLRQPRPGS
• Sequence Similarities: Contains 1 FCP1 homology domain.

Gene Information

• Gene Name: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 [ Homo sapiens ]
• Official Symbol: CTDSP1
• Synonyms: CTDSP1; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; NLIIF; nuclear LIM interactor interacting factor; SCP1; small CTD phosphatase 1
• Gene ID: 58190
• mRNA Refseq: NM_001206878
• Protein Refseq: NP_001193807
• MIM: 605323
• Uniprot ID: Q9GZU7
• Chromosome Location: 2q35
• Pathway: BMP receptor signaling, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; Regulation of cytoplasmic and nuclear SMAD2/3 signaling, organism-specific biosystem
• Function: CTD phosphatase activity; hydrolase activity; metal ion binding; phosphoprotein phosphatase activity; protein binding