Recombinant Human Complement Component 5a Receptor 1, His-tagged
| Cat.No. : | C5AR1-4908H |
| Product Overview : | The recombinant protein is not further processed to remove the additional sequence. |
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| Cat. No. : | C5AR1-4908H |
| Description : | C5AR1 complement activation from the a-chain of complement C5. C5AR1 is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. The 74 amino acid, C5AR1 protein expressed in E. coli with a 6 amino acid, N-terminal His·Tag sequence and 28 amino acid proprietary vector sequence necessary for expression. |
| Biological Activity : | Human recombinant C5AR1 is as active as that of serum derived C5AR1 based on enzyme release assay of myeloperoxidase. The current lot of EDS25;S20; = 1.36 nmolar. |
| Molecular Weight : | 74 amino acids |
| Source : | E. coli |
| Species : | Human |
| Form : | Lyophilized with no additives. |
| Appearance : | Lyophilized protein |
| Endotoxin Level : | <0.1 ng/μg |
| Reconstitution : | Reconstitute to a concentration of 1.0 mg/ml in ice-cold water containing 2.5 mg/ml BSA. The solution should be aliquoted and immediately stored at -70°C for future use. Frozen/thaw will result in some loss of activity. |
| Purity : | ≥95% by SDS-PAGE |
| Storage : | Store at -20°C or -70°C as supplied. Stable for at least 1 year. After reconstition, store at -70°C. |
| Pathways : | Class A/1 (Rhodopsin-like receptors); Complement and Coagulation Cascades; G alpha (i) signalling events; GPCR downstream signaling; GPCR ligand binding; Neuroactive ligand-receptor interaction; Peptide GPCRs; Peptide ligand-binding receptors; Signaling by GPCR; Staphylococcus aureus infection |
| Tag : | Non |
| Gene Name | C5AR1 complement component 5a receptor 1 [ Homo sapiens ] |
| Official Symbol | C5AR1 |
| Synonyms | C5AR1; complement component 5a receptor 1; C5A; C5AR; C5R1; CD88; C5a anaphylatoxin chemotactic receptor; C5a-R; C5a ligand; C5a anaphylatoxin receptor; complement component 5 receptor 1 |
| Gene ID | 728 |
| mRNA Refseq | NM_001736 |
| Protein Refseq | NP_001727 |
| MIM | 113995 |
| UniProt ID | P21730 |
| Chromosome Location | 19q13.3-q13.4 |
| Function | C5a anaphylatoxin receptor activity; G-protein coupled receptor activity; receptor activity; signal transducer activity |
Not For Human Consumption!
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