Recombinant Human CLP1 protein, MYC/DDK-tagged

• Cat.No.: CLP1-185H
• Product Overview: Recombinant Human CLP1, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 47.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: CLP1 cleavage and polyadenylation factor I subunit 1 [ Homo sapiens ]
• Official Symbol: CLP1
• Synonyms: HEAB; hClp1; ATP/GTP-binding protein; CLP1; homolog of yeast CFIA subunit Clp1p; polyadenylation factor Clp1; polynucleotide kinase Clp1; pre-mRNA cleavage complex II protein Clp1
• Gene ID: 10978
• mRNA Refseq: NM_006831
• Protein Refseq: NP_006822
• MIM: 608757
• UniProt ID: Q92989
• Chromosome Location: 11q12
• Pathway: Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem; mRNA 3'-end processing, organism-specific biosystem; mRNA surveillance pathway, conserved biosystem
• Function: ATP binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; polydeoxyribonucleotide kinase activity