Recombinant Human CHMP4B, GST-tagged

• Cat.No.: CHMP4B-11187H
• Product Overview: Recombinant Human CHMP4B protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-224a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CHMP4B charged multivesicular body protein 4B [ Homo sapiens ]
• Official Symbol: CHMP4B
• Synonyms: CHMP4B; charged multivesicular body protein 4B; C20orf178, chromatin modifying protein 4B , chromosome 20 open reading frame 178; charged multivesicular body protein 4b; dJ553F4.4; Shax1; SNF7 2; VPS32B; hSnf7-2; hVps32-2; chromatin modifying protein 4B; chromatin-modifying protein 4b; SNF7 homolog associated with Alix 1; Snf7 homologue associated with Alix 1; vacuolar protein sorting-associated protein 32-2; vacuolar protein-sorting-associated protein 32-2; SNF7; CTPP3; CHMP4A; SNF7-2; Vps32-2; C20orf178
• Gene ID: 128866
• mRNA Refseq: NM_176812
• Protein Refseq: NP_789782
• MIM: 610897
• UniProt ID: Q9H444
• Chromosome Location: 20q11.22
• Pathway: ESCRT-III complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem; Membrane Trafficking, organism-specific biosystem
• Function: protein binding