Recombinant Human Chemokine (C-C Motif) Ligand 28, His-tagged

• Cat.No.: CCL28-113H
• Product Overview: Recombinant Human CCL28 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 14.3 kDa (126aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: CCL28, also known as chemokine (C-C motif) ligand 28 or mucosae-associated epithelial chemokine(MEC), belongs to the subfamily of small cytokine CC proteins. CCL28 is expressed by columnar epithelial cells in the gut, lung, breast and the salivary glands and drives the mucosal homing of T and B lymphocytes that express CCR10, and the migration of eosinophils expressing CCR3. This chemokine is constitutively expressed in the colon, but its levels can be increased by pro-inflammatorycytokinesand certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MILPIASSCC TEVSHHISRR LLERVNMCRI QRADGDCDLA AVILHVKRRR ICVSPHNHTV KQWMKVQAAK KNGKGNVCHR KKHHGKRNSN RAHQGKHETY GHKTPY
• Form: Liquid. In 10mM Sodium Citrate pH3.5 containing 10% Glycerol.
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: CCL28 chemokine (C-C motif) ligand 28 [ Homo sapiens ]
• Synonyms: CCL28; chemokine (C-C motif) ligand 28; MEC; CCK1; SCYA28; MGC71902; CC chemokine CCL28; small inducible cytokine A28; mucosae-associated epithelial chemokine; small inducible cytokine subfamily A (Cys-Cys), member 28; Mucosae-associated epithelial chemokine; Protein CCK1
• Gene ID: 56477
• mRNA Refseq: NM_148672
• Protein Refseq: NP_683513
• MIM: 605240
• UniProt ID: Q9NRJ3
• Chromosome Location: 5p12
• Pathway: Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Signaling by GPCR
• Function: chemokine activity