Recombinant Human Chemokine (C-C Motif) Ligand 21, His-tagged

• Cat.No.: CCL-329H
• Product Overview: Purified recombinant Human CCL21 protein.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: CCL21 is member of the chemokine superfamily and the subfamily of CC chemokines that has an aspartatecysteine-cysteine-leucine motif near its amino-terminus. This protein is involved in the inhibition of hemopoiesis and stimulates chemotaxis. CCL21 is chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. It may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. Recombinant CCL21 protein was expressed in E. coli and purified by using conventional chromatography techniques.
• Form: Supplied as a liquid in 20mM Tris buffer, pH 8.0, containing 10% glycerol and 1mM DTT.
• Molecular Mass: 14.5 kDa (132aa), confirmed by MALDI-TOF.
• AA Sequence: 24-134 amino acids: MGSSHHHHHH SSGLVPRGSH MSDGGAQDCC LKYSQRKIPA KVVRSYRKQE PSLGCSIPAI LFLPRKRSQA ELCADPKELW VQQLMQHLDK TPSPQKPAQG CRKDRGASKT GKKGKGSKGC KRTERSQTPK GP
• Purity: >90% pure
• Storage: Store at 4oC for short term storage (1-2 weeks). Aliquot and store at -20oC or - 70oC for long term storage. Avoid repeated freeze/thaw cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: CCL21 chemokine (C-C motif) ligand 21 [ Homo sapiens ]
• Official Symbol: CCL21
• Synonyms: CCL21; chemokine (C-C motif) ligand 21; SCYA21, small inducible cytokine subfamily A (Cys Cys), member 21; C-C motif chemokine 21; 6Ckine; beta chemokine exodus 2; CKb9; ECL; Efficient Chemoattractant for Lymphocytes; exodus 2; secondary lymphoid tissue chemokine; SLC; TCA4; exodus-2; beta chemokine exodus-2; beta-chemokine exodus-2; small-inducible cytokine A21; secondary lymphoid-tissue chemokine; small inducible cytokine subfamily A (Cys-Cys), member 21; SCYA21; MGC34555
• Gene ID: 6366
• mRNA Refseq: NM_002989
• Protein Refseq: NP_002980
• MIM: 602737
• UniProt ID: O00585
• Chromosome Location: 9p13
• Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem
• Function: CCR7 chemokine receptor binding; chemokine activity; chemokine activity