Recombinant Human CHEK1 protein, Flag-tagged, Biotinylated

• Cat.No.: CHEK1-39H
• Product Overview: Recombinant Human CHK1 [1-476(end) amino acids of accession number NP_001265.1] fused with DYKDDDDK tag at N-terminal was expressed in insect cell and biotinylated.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Flag
• Protein Length: 1-476 a.a.
• Form: 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
• Molecular Mass: 58 kDa
• Purity: >95% as determined by SDS-PAGE and CBB staining
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: CHEK1 checkpoint kinase 1 [ Homo sapiens ]
• Official Symbol: CHEK1
• Synonyms: CHEK1; checkpoint kinase 1; CHK1; Chk1-S; checkpoint kinase-1
• Gene ID: 1111
• mRNA Refseq: NM_001114121
• Protein Refseq: NP_001107593
• MIM: 603078
• UniProt ID: O14757
• Chromosome Location: 11q24.2
• Pathway: Activation of ATR in response to replication stress, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, organism-specific biosystem
• Function: ATP binding; histone kinase activity (H3-T11 specific); nucleotide binding; protein binding; protein serine/threonine kinase activity