Recombinant Human CGB3 protein, His-tagged

• Cat.No.: CGB3-130H
• Product Overview: Recombinant Human CGB3(21-165aa) fused with His tag at C-terminal was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 21-165 a.a.
• Description: CGB3, also known as choriogonadotropin subunit beta, is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). It stimulates the expression of GCM1 target genes, including the fusogenic protein syncytin-1, to promote placental cell fusion. It synthesized in large quantities by the developing placenta, reaching peak concentrations in maternal blood during the late first trimester and early midtrimester of pregnancy. It is expressed exclusively by trophoblasts. It is an important biomarker in pregnancy and oncology, where it is routinely detected and quantified by specific immunoassays.
• Form: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
• Molecular Mass: 16.6kDa (154aa)
  18-28kDa (SDS-PAGE under reducing conditions)
• AA Sequence: ADPSKEPLRP RCRPINATLA VEKEGCPVCI TVNTTICAGY CPTMTRVLQG VLPALPQVVC NYRDVRFESI RLPGCPRGVN PVVSYAVALS
  CQCALCRRST TDCGGPKDHP LTCDDPRFQD SSSSKAPPPS LPSPSRLPGP SDTPILPQHH HHHH
• Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Purity: > 90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: CGB3 chorionic gonadotropin beta subunit 3 [ Homo sapiens ]
• Official Symbol: CGB3
• Synonyms: CGB; CGB5; CGB7; CGB8; hCGB; CG-beta; chorionic gonadotrophin chain beta; chorionic gonadotropin beta 3 subunit; chorionic gonadotropin beta chain; chorionic gonadotropin chain beta; chorionic gonadotropin, beta polypeptide
• Gene ID: 1082
• mRNA Refseq: NM_000737
• Protein Refseq: NP_000728
• MIM: 118860
• UniProt ID: P0DN86
• Chromosome Location: 19q13.33
• Pathway: Gene Expression, organism-specific biosystem; Glycoprotein hormones, organism-specific biosystem; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, organism-specific biosystem