Recombinant Human CEACAM1 protein, His-tagged

• Cat.No.: CEACAM1-8192H
• Product Overview: Recombinant Human CEACAM1 aa. (Gln35~Glu320 (Accession # P13688)) fused with N-terminal His tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Gln35~Glu320
• Description: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 33.0kDa.
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 5.2.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage Buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: CEACAM1 carcinoembryonic antigen related cell adhesion molecule 1 [ Homo sapiens (human) ]
• Official Symbol: CEACAM1
• Synonyms: CEACAM1; carcinoembryonic antigen related cell adhesion molecule 1; BGP; BGP1; BGPI; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a antigen; antigen CD66; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
• Gene ID: 634
• mRNA Refseq: NM_001024912.2
• Protein Refseq: NP_001020083.1
• UniProt ID: P13688