Recombinant Human CDKN2D, GST-tagged

• Cat.No.: CDKN2D-1476H
• Product Overview: Recombinant full-length human p19INK4D was expressed inE. colicells using an N-terminal GST tag. MW = 44 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: p19INK4D protein is associated with CDK6 in several hematopoietic cell lines. It has been demonstrated that p19INK4D expression enhances cell survival under genotoxic conditions. By using p19INK4D-overexpressing cells, it has been demonstrated that p19INK4D expression correlates with the cellular resistance to UV treatment with increased DNA repair activity against UV-induced lesions. p19INK4D regulates protein network that integrate DNA repair, apoptosis and checkpoint mechanisms in order to maintain the genomic integrity.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) [ Homo sapiens ]
• Synonyms: CDKN2D; cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); p19; INK4D; p19-INK4D; cyclin-dependent kinase inhibitor 2D; CDK inhibitor p19INK4d; inhibitor of cyclin-dependent kinase 4d; cyclin-dependent kinase 4 inhibitor D p19; cell cycle inhibitor, Nur77 associating protein; Cyclin-dependent kinase 4 inhibitor D; p19-INK4d
• Gene ID: 1032
• mRNA Refseq: NM_001800
• Protein Refseq: NP_001791
• MIM: 600927
• UniProt ID: P55273
• Chromosome Location: 19p13
• Pathway: Cell cycle
• Function: cyclin-dependent protein kinase inhibitor activity; protein kinase binding