Recombinant Human CDK7/CCNH/MNAT1, His-tagged, Active

• Cat.No.: CDK7/CCNH/MNAT1-279H
• Product Overview: Recombinant human full-length CDK7, Cyclin H1 and MNATI were co-expressed by baculovirus inSf9insect cells using N-terminal His tags. MW=40kDa, Cyclin H1 ~39kDa, and MNAT1 ~37kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: His
• Description: CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression. CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CDK7 cyclin-dependent kinase 7 [ Homo sapiens ],CCNH cyclin H [ Homo sapiens ],MNAT1 menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) [ Homo sapiens ]
• Synonyms: CDK7; cyclin-dependent kinase 7; CAK1; MO15; STK1; CDKN7; p39MO15; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase);Cell division protein kinase 7;EC2.7.11.22;EC2.7.11.23; CDK-activating kinase; TFIIH basal transcription factor complex kinase subunit; 39 kDa protein kinase; P39 Mo15; CCNH; cyclin H; CAK; p34; p37; CDK-activating kinase; cyclin-dependent kinase-activating kinase; MO15-associated protein; Cyclin-H; MNAT1; menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis); MAT1; TFB3; RNF66; menage a trois 1 (CAK assembly factor); CDK-activating kinase assembly factor MAT1; CDK7/cyclin H assembly factor;p35; p36; RING finger protein 66; Cyclin G1-interacting protein
• Gene ID: 1022,902,4331
• mRNA Refseq: NM_001799,NM_001239,NM_002431
• Protein Refseq: NP_001790,NP_001230,NP_002422
• UniProt ID: P50613, P51946, P51948
• Chromosome Location: 5q12.1, 5q13.3-q14, 14q23
• MIM: 601955,601953,602659
• Pathway: Cell cycle; Cell Cycle, Mitotic; Nucleotide excision repair; DNA Repair; Gene Expression; HIV Infection; Transcription; mRNA Processing
• Function: ATP binding; DNA-dependent ATPase activity ; RNA polymerase II carboxy-terminal domain kinase activity ; androgen receptor binding; protein C-terminus binding; transcription coactivator activity; cyclin-dependent protein kinase activity; nucleotide binding; transferase activity; protein N-terminus binding; zinc ion binding