Recombinant Human CDC73, His-tagged

• Cat.No.: CDC73-7927H
• Product Overview: Recombinant Human Parafibromin is produced by our E. coli expression system. The target protein is expressed with sequence (Ala2Glu260) of Human CDC73 fused with a 6His tag at the Nterminus.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Parafibromin is expressed in the adrenal and parathyroid glands, kidney, and heart. As a tumor supressor, Parafibromin may be involved in transcriptional and posttranscriptional control pathways, also through the regulation of cyclin D1/PRAD1 expression, involved the cell cycle progression. Parafibromin is a component of the the PAF protein complex and interacts with a Set1like complex that has histone methyltransferase activity and methylates histone H3. Defects in Parafibromin can cause hyperparathyroidismjaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.
• Form: Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.4
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.

Gene Information

• Gene Name: CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: CDC73
• Synonyms: CDC73; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); C1orf28, chromosome 1 open reading frame 28 , HRPT2, hyperparathyroidism 2 (with jaw tumor); parafibromin; hyperparathyroidism 2 protein; cell division cycle protein 73 homolog; HYX; HPTJT; HRPT2; C1orf28; FLJ23316
• Gene ID: 79577
• mRNA Refseq: NM_024529
• Protein Refseq: NP_078805
• MIM: 607393
• UniProt ID: Q6P1J9
• Chromosome Location: 1q25
• Function: protein binding