Recombinant Human CDC23, GST-tagged

• Cat.No.: CDC23-10998H
• Product Overview: Recombinant Human CDC23 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: N-term-126a.a.
• Description: This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CDC23 cell division cycle 23 homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: CDC23
• Synonyms: CDC23; cell division cycle 23 homolog (S. cerevisiae); CDC23 (cell division cycle 23, yeast, homolog); cell division cycle protein 23 homolog; ANAPC8; anaphase promoting complex subunit 8; APC8; CUT23; cyclosome subunit 8; anaphase-promoting complex subunit 8
• Gene ID: 8697
• mRNA Refseq: NM_004661
• Protein Refseq: NP_004652
• MIM: 603462
• UniProt ID: Q9UJX2
• Chromosome Location: 5q31
• Pathway: APC/C complex, organism-specific biosystem; APC/C complex, conserved biosystem; APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem
• Function: binding; ubiquitin-protein ligase activity