Recombinant Human CD86

• Cat.No.: CD86-27891TH
• Product Overview: Recombinant full length Human CD86 with proprietary tag, 62.26kDa inclusive of tag.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 329 amino acids
• Description: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
• Molecular Weight: 62.260kDa inclusive of tags
• Tissue specificity: Expressed by activated B-lymphocytes and monocytes.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPC QFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSV HSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPT GMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLT CSSIHGYPEPKKMSVLLRTKNSTIEYDGIMQKSQDNVTEL YDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSI ELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKK RPRNSYKCGTNTMEREESEQTKKREKIHIPERSDETQR VFKSSKTSSCDKSDTCF
• Sequence Similarities: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Gene Information

• Gene Name: CD86 CD86 molecule [ Homo sapiens ]
• Official Symbol: CD86
• Synonyms: CD86; CD86 molecule; CD28LG2, CD86 antigen (CD28 antigen ligand 2, B7 2 antigen); T-lymphocyte activation antigen CD86; B lymphocyte antigen B7 2; B7 2; B7.2
• Gene ID: 942
• mRNA Refseq: NM_001206924
• Protein Refseq: NP_001193853
• MIM: 601020
• Uniprot ID: P42081
• Chromosome Location: 3q21
• Pathway: Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem
• Function: coreceptor activity; protein binding; receptor activity