Recombinant Human CD4 Molecule, His-tagged(203-317aa)
Cat.No. : | CD4-102H |
Product Overview : | Recombinant Human CD-4 produced in Escherichia Coli encodes amino acids 203-317and fused to His Tag protein. |
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Species : | Human |
Source : | E.coli |
Tag : | Non |
Protein Length : | 203-317 a.a. |
Description : | CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV. Antibody to CD4 recognizes T-helper cells required for recognition of class II antigens. It reacts with ~60% of peripheral blood E rosette-positive (E+) cells while showing negligible reactivity with E- cells, monocytes, granulocytes, EBV-transformed B cell lines, and mouse splenocytes. |
Physical Appearance : | Sterile lyophilized powder. |
Formulation : | Each mg contains 1X PBS, 0.1% SDS and 1mM DTT. |
Application and Suggested Dilutions : | • Protein Assay • Antibody Production • Western Blotting |
Storage : | Store vial at -20oC to -80oC. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles. |
Gene Name | CD4 CD4 molecule [ Homo sapiens ] |
Synonyms | CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD antigen; CD4 antigen; CD4 receptor |
Gene ID | 920 |
mRNA Refseq | NM_000616 |
Protein Refseq | NP_000607 |
MIM | 186940 |
UniProt ID | P01730 |
Chromosome Location | 12pter-p12 |
Pathway | Antigen processing and presentation; Cell adhesion molecules (CAMs); Hematopoietic cell lineage; Primary immunodeficiency; T cell receptor signaling pathway; HIV Infection; Signaling in Immune system |
Function | MHC class II protein binding; coreceptor activity; extracellular matrix structural constituent; protein homodimerization activity; protein kinase binding; transmembrane receptor activity; zinc ion binding |
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Not For Human Consumption!
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