Recombinant Human CD300A Protein, His-tagged

• Cat.No.: CD300A-015H
• Product Overview: Recombinant Human CD300A Protein with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: CD300a is an inhibitory receptor in the Ig superfamily, a type I transmembrane protein containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on its cytoplasmic tail. Human CD300a (CMRF-35H, IRp60) and mouse CD300a (CLM-8, LMIR-1, MAIR-I) are functional orthologs, expressed by monocytes, granulocytes, mast cells, and subsets of B cells. Human, but not mouse, CD300a is also expressed by unstimulated NK cells and subsets of T cells. Phosphorylated ITIMs are able to recruit different phosphatases, such as SHP-1 and SHP-2, leading to inhibition of cell activation.
• Molecular Mass: ~23 kDa
• AA Sequence: LSKCRTVAGPVGGSLSVQCPYEKEHRTLNKYWCRPPQIFLCDKIVETKGSAGKRNGRVSIRDSPANLSFTVTLENLTEEDAGTYWCGVDTPWLRDFHDPVVEVEVSVFPASTSMTPASITAAKTSTITTAFPPVSSTTLFAVGATHSASIQEETEEVVNSQLP
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: CD300A CD300a molecule [ Homo sapiens (human) ]
• Official Symbol: CD300A
• Synonyms: CD300A; CD300a molecule; CD300a antigen; CMRF35-like molecule 8; CMRF 35 H9; CMRF35H; IGSF12; IRC1; IRC2; Irp60; NK inhibitory receptor; leukocyte membrane antigen; inhibitory receptor protein 60; CD300 antigen-like family member A; immunoglobulin superfamily member 12; CMRF35H leukocyte immunoglobulin-like receptor; CLM-8; IRp60; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9
• Gene ID: 11314
• mRNA Refseq: NM_001256841
• Protein Refseq: NP_001243770
• MIM: 606790
• UniProt ID: Q9UGN4