Recombinant Human CD300A protein, Fc-tagged

• Cat.No.: CD300A-267H
• Product Overview: Recombinant Human CD300A (Leu18-Gln178) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: Leu18-Gln178
• Description: CD300 antigen-like family member A (CD300A) is also known as CMRF35-like molecule 8 (CLM-8), CMRF-35-H9, CMRF35-H, Immunoglobulin superfamily member 12 (IGSF12), NK inhibitory receptor, LMIR1, which belongs to the CD300 family. CD300A contains one Ig-like V-type (immunoglobulin-like) domain. CD300A is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. CD300A is a inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.
• Predicted N Terminal: Leu18
• Form: Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 44 kDa. As a result of glycosylation, the protein migrates as 52-66 kDa under reducing (R) condition, and 105-130 kDa under non-reducing (NR) condition (SDS-PAGE).
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: CD300A
• Official Symbol: CD300A
• Synonyms: CD300A; CD300a molecule; CD300a antigen; CMRF35-like molecule 8; CMRF 35 H9; CMRF35H; IGSF12; IRC1; IRC2; Irp60; NK inhibitory receptor; leukocyte membrane antigen; inhibitory receptor protein 60; CD300 antigen-like family member A; immunoglobulin superfamily member 12; CMRF35H leukocyte immunoglobulin-like receptor; CLM-8; IRp60; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9
• Gene ID: 11314
• mRNA Refseq: NM_001256841
• Protein Refseq: NP_001243770
• MIM: 606790
• UniProt ID: Q9UGN4