Recombinant Human CD22 Molecule, Extracellular Domain

• Cat.No.: CD22-960H
• Product Overview: Recombinant Human solube CD22 molecule produced inCHOwas a 75.0kDa (666 amino acid residues) protein which corresponds to the extracellular domain of CD22.

Specification

• Species: Human
• Source: CHO
• Tag: Non
• Description: CD22 is a 135kDa B-cell restricted sialoglycoprotein that binds to oligosaccharides containing 2-6-linked sialic acid residues. It is present in the cytoplasm of nearly all B-lineage cells and is also expressed on the surface of B-cells during advance stages of differentiation. Although the exact physiological function of CD22 is unclear, it appears to play a role in B-cell activation and to act as an adhesion molecule. The potential therapeutic use of CD22 and anti-CD22 may be useful in diagnostic and/or treatment of leukemia, lymphoma, non-Hodgkin"s lymphoma and certain autoimmune conditions.
• Purity: >95%by SDS-PAGE and HPLC analyses.
• Endotoxin level: <0.1ng/ μg of sCD22.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biological Activity: Data not available at this time.
• Reconstitution: We recommended a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers and stored at 4°C for one week or at –20°C for future use.
• Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted sCD22 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: CD22 CD22 molecule [ Homo sapiens ]
• Synonyms: CD22 CD22 molecule; SIGLEC2; FLJ22814; SIGLEC-2; MGC130020; CD22 antigen; Siglec-2; B-cell receptor CD22; Sialic acid-binding Ig-like lectin 2; Siglec-2; Leu-14; B-lymphocyte cell adhesion molecule; BL-CAM
• Gene ID: 933
• mRNA Refseq: NM_001771
• Protein Refseq: NP_001762
• MIM: 107266
• UniProt ID: P20273
• Chromosome Location: 19q13.1
• Pathway: B cell receptor signaling pathway; Cell adhesion molecules (CAMs); Hematopoietic cell lineage
• Function: protein binding; sugar binding