Recombinant Human CCL5 Protein, Biotin-tagged

• Cat.No.: CCL5-57H
• Product Overview: Recombinant Human CCL5 Protein, fused to Biotin-tag, was expressed in E. coli.

Specification

• Description: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
• Source: E. coli
• Species: Human
• Tag: Biotin
• AA Sequence: SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS + Linker
• tmpcolum67: C-C motif chemokine ligand 5

Gene Information

• Gene Name: CCL5 C-C motif chemokine ligand 5 [ Homo sapiens (human) ]
• Official Symbol: CCL5
• Synonyms: SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta
• Gene ID: 6352
• mRNA Refseq: NM_002985
• Protein Refseq: NP_002976
• MIM: 187011
• UniProt ID: P13501