Recombinant Human CCBL1, His-tagged

• Cat.No.: CCBL1-82H
• Product Overview: Recombinant human CCBL1 was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-422 aa
• Description: CCBL1 also known as Kynurenine--oxoglutrate transaminase1 isoform a. CCBL1 catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) and it metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. CCBL1 catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno) cysteine, resulting in the cleavage of the C-S or C-Se bond.
• Form: Liquid. In Phosphate buffered saline (pH7.4) containing 10% glycerol, 1mM DTT
• Molecular Mass: 50.3kDa (445aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAKQLQA RRLDGIDYNP WVEFVKLASE HDVVNLGQGF PDFPPPDFAV EAFQHAVSGD FMLNQYTKTF GYPPLTKILA SFFGELLGQE IDPLRNVLVT VGGYGALFTA FQALVDEGDE VIIIEPFFDC YEPMTMMAGG RPVFVSLKPG PIQNGELGSS SNWQLDPMEL AGKFTSRTKA LVLNTPNNPL GKVFSREELE LVASLCQQHD VVCITDEVYQ WMVYDGHQHI SIASLPGMWE RTLTIGSAGK TFSATGWKVG WVLGPDHIMK HLRTVHQNSV FHCPTQSQAA VAESFEREQL LFRQPSSYFV QFPQAMQRCR DHMIRSLQSV GLKPIIPQGS YFLITDISDF KRKMPDLPGA VDEPYDRRFV KWMIKNKGLV AIPVSIFYSV PHQKHFDHYI RFCFVKDEAT LQAMDEKLRK WKVEL
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: CCBL1 cysteine conjugate-beta lyase, cytoplasmic [ Homo sapiens ]
• Official Symbol: CCBL1
• Synonyms: CCBL1; cysteine conjugate-beta lyase, cytoplasmic; cysteine conjugate beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); kynurenine--oxoglutarate transaminase 1; glutamine transaminase K; GTK; KATI; kyneurenine aminotransferase; beta-lysase, kidney; kynurenine aminotransferase I; cysteine-S-conjugate beta-lyase; glutamine--phenylpyruvate transaminase; kynurenine--oxoglutarate transaminase I; glutamine-phenylpyruvate aminotransferase; cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); KAT1; FLJ95217; MGC29624
• Gene ID: 883
• mRNA Refseq: NM_001122671
• Protein Refseq: NP_001116143
• MIM: 600547
• UniProt ID: Q16773
• Chromosome Location: 9q34.11
• Pathway: Amino acid synthesis and interconversion (transamination), organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Phenylalanine and tyrosine catabolism, organism-specific biosystem; Selenocompound metabolism, organism-specific biosystem; Selenocompound metabolism, conserved biosystem
• Function: 1-aminocyclopropane-1-carboxylate synthase activity; L-glutamine:pyruvate aminotransferase activity; L-phenylalanine:pyruvate aminotransferase activity; cysteine-S-conjugate beta-lyase activity; glutamine-phenylpyruvate transaminase activity; kynurenine-oxoglutarate transaminase activity; kynurenine-oxoglutarate transaminase activity; lyase activity; protein homodimerization activity; pyridoxal phosphate binding; transaminase activity; transferase activity, transferring nitrogenous groups