Recombinant Human CBX1, His-tagged

• Cat.No.: CBX1-3580H
• Product Overview: Recombinant human CBX1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (1-185 aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: CBX1 is a member of the heterochromatin protein family and enriched in the heterochromatin and associated with centromeres. It is recognizes and binds histone H3 tails methylated at "Lys-9", leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. This protein may play an important role in the epigenetic control of chromatin structure and gene expression.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 2mM DTT, 0.1M NaCl.
• Molecular Weight: 23.6 kDa (205aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
• Purity: > 85 % by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGKKQNKKKV EEVLEEEEEE YVVEKVLDRR VVKGKVEYLL KWKGFSDEDN TWEPEENLDC PDLIAEFLQS QKTAHETDKS EGGKRKADSD SEDKGEESKP KKKKEESEKP RGFARGLEPE RIIGATDSSG ELMFLMKWKN SDEADLVPAK EANVKCPQVV ISFYEERLTW HSYPSEDDDK KDDKN
• Storage: Can be stored at +4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20℃ or -70℃. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: CBX1 chromobox homolog 1 [ Homo sapiens ]
• Official Symbol: CBX1
• Synonyms: CBX1; CBX; M31; MOD1; p25beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta; chromobox homolog 1; chromobox protein homolog 1; HP1 beta homolog; OTTHUMP00000197313; OTTHUMP00000197314; OTTHUMP00000197316; modifier 1 protein; heterochromatin protein 1-beta; heterochromatin protein p25 beta; heterochromatin protein 1 homolog beta; chromobox homolog 1 (HP1 beta homolog Drosophila ); chromobox homolog 1 (Drosophila HP1 beta); HP1 beta homolog (Drosophila); Chromobox protein homolog 1; Heterochromatin protein 1 homolog beta; HP1 beta; Heterochromatin protein p25; Modifier 1 protein; OTTHUMP00000197315
• Gene ID: 10951
• mRNA Refseq: NM_001127228
• Protein Refseq: NP_001120700
• MIM: 604511
• UniProt ID: P83916
• Chromosome Location: 17q21.32
• Function: chromatin binding; enzyme binding; protein binding; transcription repressor activity