Recombinant Human CAVIN1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CAVIN1-3609H
• Product Overview: PTRF MS Standard C13 and N15-labeled recombinant protein (NP_036364) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 43.3 kDa
• AA Sequence: MEDPTLYIVERPLPGYPDAEAPEPSSAGAQAAEEPSGAGSEELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLEERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIKKLEVNEAELLRRRNFKVMIYQDEVKLPAKLSISKSLKESEALPEKEGEELGEGERPEEDAAALELSSDEAVEVEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEKTKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPAERREKLKTSXDKLRKSFTPDHVVYARSKTAVYKVPPFTFHVKKIREGQVEVLKATEMVEVGADDDEGGAERGEAGDLRRGSSPDVHALLEITEESDAVLVDKSDSDTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CAVIN1 caveolae associated protein 1 [ Homo sapiens (human) ]
• Official Symbol: CAVIN1
• Synonyms: CAVIN1; caveolae associated protein 1; CGL4; PTRF; CAVIN; FKSG13; cavin-1; caveolae-associated protein 1; RNA polymerase I and transcript release factor; TTF-I interacting peptide 12; congenital generalized lipodystrophy 4; polymerase I and transcript release factor
• Gene ID: 284119
• mRNA Refseq: NM_012232
• Protein Refseq: NP_036364
• MIM: 603198
• UniProt ID: Q6NZI2