Recombinant Human Cathepsin D

• Cat.No.: CTSD-90H
• Product Overview: Recombinant full length human Catheprsin D protein expressed inE.coli,48kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Cathepsin D is synthesized as a 54kDa precursor, which is proteolytically processed to an intermediate 48kDa single chain, which matures into more stable 34kDa and 14kDa two chain form. It is an estrogen-regulated lysosomal protease that has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and xonnective tissue. Because of its mitogenic and proteolytic activities, it has been implicated as a prognostic marker in many tumor types. Cathepsin D is expressed in epithelial cells as well as in macrophages.
• Presentation: 5µg/50µl purified human Cathepsin D protein at 0.1mg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
• Applications: •ELISA •Inhibition Assays •Western Blotting
• Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 48kDa.
• Activity: Not known.
• Storage: Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
• Full Length: Full L.

Gene Information

• Gene Name: CTSD cathepsin D [ Homo sapiens ]
• Synonyms: CTSD; cathepsin D; CPSD; CLN10; MGC2311; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; EC 3.4.23.5; cathepsin D (lysosomal aspartyl protease);Cathepsin D light chain; Cathepsin D heavy chain
• Gene ID: 1509
• mRNA Refseq: NM_001909
• Protein Refseq: NP_001900
• MIM: 116840
• UniProt ID: P07339
• Chromosome Location: 11p15.5
• Pathway: Lysosome
• Function: aspartic-type endopeptidase activity; peptidase activity