Recombinant Human CAPN6, GST-tagged

• Cat.No.: CAPN6-10705H
• Product Overview: Recombinant Human CAPN6 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimers disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimers disease.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 67-360a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CAPN6 calpain 6 [ Homo sapiens ]
• Official Symbol: CAPN6
• Synonyms: CALP M; Calpain-6; Calpain-like protease X-linked; Calpamodulin; CALPM; CAN6_HUMAN; CANP X; CANPX; CAPN 6; CAPN6
• Gene ID: 827
• mRNA Refseq: NM_014289.3
• Protein Refseq: NP_055104.2
• MIM: 300146
• UniProt ID: Q9Y6Q1
• Chromosome Location: Xq23
• Pathway: Integrin-mediated cell adhesion, organism-specific biosystem
• Function: calcium-dependent cysteine-type endopeptidase activity; microtubule binding