Recombinant Human CAP1 Protein (Ala38-Lys149), His tagged

• Cat.No.: CAP1-0693H
• Product Overview: Recombinant human CAP1 (Ala38-Lys149) fused with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Ala38-Lys149
• Description: Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 13.61 kDa
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles.
  Store at 2 to 8 centigrade for one week.
  Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) [ Homo sapiens (human) ]
• Official Symbol: CAP1
• Synonyms: CAP1; CAP, adenylate cyclase-associated protein 1 (yeast); adenylyl cyclase-associated protein 1; CAP; CAP 1; CAP1-PEN
• Gene ID: 10487
• mRNA Refseq: NM_001105530
• Protein Refseq: NP_001099000
• MIM: 617801
• UniProt ID: Q01518